Table II.
Side effects and toxicities associated with XELOX-70, XELOX-130 and FOLFOX-4.
| XELOX-70 | XELOX-130 | FOLFOX-4 | |
|---|---|---|---|
| n | 17 | 17 | 20 |
| Median age (years) | 66,72 | 67,24 | 61,68 |
| Toxicity according to CTC (%) | |||
| Fatigue (grade) | |||
| 0 | 24 | 0 | 40 |
| 1/2 | 52 | 76 | 40 |
| 3/4 | 24 | 24 | 20 |
| 1–4 | 76 | 100 | 60 |
| Nausea (grade) | |||
| 0 | 18 | 41 | 55 |
| 1/2 | 76 | 41 | 35 |
| 3/4 | 6 | 18 | 10 |
| 1–4 | 82 | 59 | 45 |
| Emesis (grade) | |||
| 0 | 41 | 65 | 65 |
| 1/2 | 41 | 24 | 30 |
| 3/4 | 18 | 11 | 5 |
| 1–4 | 59 | 35 | 35 |
| Diarrhea (grade) | |||
| 0 | 29 | 52 | 55 |
| 1/2 | 65 | 41 | 40 |
| 3/4 | 6 | 6 | 5 |
| 1–4 | 59 | 35 | 35 |
| Mucositis (grade) | |||
| 0 | 48 | 52 | 50 |
| 1/2 | 52 | 48 | 45 |
| 3/4 | 0 | 0 | 5 |
| 1–4 | 52 | 48 | 50 |
| Exanthema (grade) | |||
| 0 | 59 | 70 | 85 |
| 1/2 | 41 | 30 | 10 |
| 3/4 | 0 | 0 | 5 |
| 1–4 | 41 | 30 | 15 |
| HFS (grade) | |||
| 0 | 59 | 48 | 45 |
| 1/2 | 30 | 48 | 50 |
| 3/4 | 11 | 6 | 5 |
| 1–4 | 41 | 54 | 55 |
| Paresthesia (grade) | |||
| 0 | 18 | 6 | 25 |
| 1/2 | 70 | 83 | 65 |
| 3/4 | 11 | 11 | 10 |
| 1–4 | 81 | 94 | 75 |
| 1–4 | 35 | 17 | 30 |
| Pain (grade) | |||
| 0 | 24 | 30 | 60 |
| 1/2 | 70 | 65 | 30 |
| 3/4 | 6 | 6 | 10 |
| 1–4 | 76 | 71 | 40 |
| Alopecia (grade) | |||
| 0 | 59 | 70 | 75 |
| 1/2 | 41 | 30 | 25 |
| 3/4 | 0 | 0 | 0 |
| 1–4 | 41 | 30 | 25 |
| Loss of weight (grade) | |||
| 0 | 65 | 70 | 85 |
| 1/2 | 35 | 30 | 15 |
| 3/4 | 0 | 0 | 0 |
| 1–4 | 35 | 30 | 15 |
| Infections (grade) | |||
| 0 | 65 | 83 | 70 |
| 1/2 | 11 | 11 | 30 |
| 3/4 | 24 | 6 | 0 |
The side effects in percentages observed using the mentioned chemotherapy regimens and their severity according to CTC are shown. HFS, hand-foot syndrome.