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. Author manuscript; available in PMC: 2013 Jul 6.
Published in final edited form as: Cell Stem Cell. 2012 Jul 6;11(1):50–61. doi: 10.1016/j.stem.2012.04.009

Figure 1. KDM4B and KDM6B were induced by BMP/SMAD signaling in MSCs.

Figure 1

(A) BMP4/7-induced histone demethylases in MSC by gene expression profiling. The mRNA expression of histone demethylases was assessed by Real-time RT-PCR. (B) The knock-down of SMAD4 by shRNA. SMAD4 expression was examined by Western Blot analysis. (C) The knock-down of SMAD4 inhibited KDM4B in MSCs. KDM4B mRNA was examined by Real-time RT-PCR. (D) The knock-down of SMAD4 inhibited KDM6B expression in MSCs. KDM6B mRNA levels were assessed by Real-time RT-PCR. ** P < 0.01. (E) The knock-down of SMAD1 by siRNA. (F) The knock-down of SMAD1 inhibited KDM4B in MSCs. (G) The knock-down of SMAD1 inhibited KDM6B expression in MSCs. ** P < 0.01. See also Figure S1.