Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2012 Mar 7;23(6):647–657. doi: 10.1089/hum.2011.177

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2012, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 6. — Mitochondrial gene therapy increases respiration in LS cells. (A) Two weeks after exposure to mtDNA+rhTFAM (gray) or rhTFAM only (black), LS cells showed increased respiration, increased sensitivity to oligomycin, and lowered uncoupled respiration compared with untreated CTL (beige). Respiration is expressed as pmol of O₂/(sec/10⁶ cells). (B) A recording of the different aspects of the respiration profile of LS (CTL) cells after 2 weeks. (C) An overlay of the respiration recording of LS cells treated with mtDNA+rhTFAM (green) over CTL (red). (D) Two to 3 weeks after exposure to mtDNA+rhTFAM (gray), LS cells showed increased ROUTINE respiration compared with rhTFAM only (black). Respiration is expressed as pmol of O₂/(sec/10⁶ cells). (E) mtDNA+rhTFAM treatment but not rhTFAM alone increased oligomycin-sensitive LEAK respiration after 2 and 3 weeks.