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. 2012 Sep 15;17(6):890–901. doi: 10.1089/ars.2011.4161

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Copyright 2012, Mary Ann Liebert, Inc.

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FIG. 6. — Loss of RNA interference rescues thermotolerance in nematodes with genetic defects of H₂O₂ disposal. (A) Effect of dcr-1(RNAi) on thermotolerance of N2 and ctl-2(ok1137) worms. ctl-2(ok1137) worms exhibited significantly shorter survival (p<0.001), while other survivals were not significantly different (p>0.2), compared to N2 control. (B) pash-1(RNAi) phenocopies dcr-1(RNAi) by inducing a significant increase in thermotolerance of ctl-2(ok1137) (p<0.0001) compared to that of the EV control. (C) pash-1(RNAi) does not change thermotolerance of wild-type worms (p>0.1) compared to that of the EV control. (D) pash-1(RNAi) extends thermotolerance independently of hsf-1 in ctl-2(ok1137) worms [p<0.01 vs. pash-1/hsf-1(RNAi)]. (E) Effect of dcr-1(RNAi) on thermotolerance of N2 and prdx-2(gk169) worms. prdx-2(gk169) worms fed by EV exhibited significantly shorter (p<0.0001), while those fed by dcr-1(RNAi) exhibited slightly longer survival (p<0.05) compared to N2 control. Survival curves are representatives of three independent experiments giving similar results.