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NHEJ inhibition is responsible for increases in gene targeting seen with vanillin. Frequencies of corrected nodules were quantified by counting the number of FAH+ clones per x hepatocytes (1/x) from neonates harvested at 3 weeks posttreatment. Mean and SD are shown, with the number of independent animals analyzed above each bar. Black, Fah−/−Ku70+/+; white, Fah−/−Ku70+/−; gray, Fah−/−Ku70−/−.
