. 2012 Jun 20;5:175–192. doi: 10.2147/JPR.S26367

Table 1.

Comparison of properties of high-threshold mechanoreceptive and low-threshold mechanoreceptive dorsal root ganglion neurons between control and neuropathic rats

CV range	Receptor class	Model	n	CV (m/s)	Vm (–mV)	APA (mV)	APdB (ms)	APRT (ms)	APFT (ms)	MRR (mV/ms)	MFR (mV/ms)	AHPA (mV)	AHP₅₀ (ms)
C	HTM	Control	21	0.59 ± 0.040	62.12 ± 2.130	83.80 ± 2.092	3.76 ± 0.247	l.47 ± 0.092	2.27 ± 0.181	146.5 ± 8.587	60.89 ± 3.390	8.73 ± 0.877	11.14 ± 1.888
		NeP	28	0.60 ± 0.036	60.35 ± 1.626	77.58 ± 2.725	3.99 ± 0.296	1.41 ± 0.111	2.40 ± 0.210	151.5 ± 10.81	58.04 ± 3.039	9.68 ± 0.771	10.95 ± 1.614
				P = 0.8355	P = 0.5061	P = 0.0934	P = 0.5741	P = 0.6801	P = 0.6515	P = 0.7354	P = 0.5356	P = 0.4217	P = 0.9417
	LTM	Control	8	0.47 ± 0.058	72.79 ± 1.866	70.89 ± 3.526	3.37 ± 0.273	1.28 ± 0.096	2.16 ± 0.177	161.5 ± 18.85	73.94 ± 1.437	1.40 ± 0.437	10.05 ± 1.054
		NeP	8	0.50 ± 0.033	71.62 ± 1.817	71.10 ± 2.91	3.19 ± 0.267	1.30 ± 0.052	2.26 ± 0.236	173.4 ± 10.91	71.27 ± 1.84	1.78 ± 0.347	9.68 ± 0.861
				P = 0.6855	P = 0.6583	P = 0.9579	P = 0.6361	P = 0.8836	P = 0.7336	P = 0.5925	P = 0.2878	P = 0.5069	P = 0.7869
	Unresponsive	Control	4	0.60 ± 0.054	59.67 ± 5.840	82.71 ± 4.650	3.74 ± 0.429	1.45 ± 0.246	2.18 ± 0.826	147.7 ± 22.08	68.29 ± 5.938	8.67 ± 3.346	11.56 ± 2278
		Nep	4	0.61 ± 0.094	59.59 ± 6.306	74.37 ± 7.491	3.95 ± 1.139	l.44 ± 0.334	2.10 ± 0.686	154.0 ± 43.60	59.51 ± 4.406	8.09 ± 1.659	11.86 ± 2.856
				P = 0.9469	P = 0.9933	P = 0.3811	P = 0.8718	P = 0.9769	P = 0.9377	P = 0.9016	P = 0.2801	P = 0.8802	P = 0.9372
Aσ	HTM	Control	11	4.32 ± 0.514	53.96 ± 3.875	74.70 ± 3.300	2.49 ± 0.289	1.03 ± 0.123	1.40 ± 0.204	193.5 ± 13.69	84.53 ± 12.50	9.51 ± 1.494	9.68 ± 2.241
		NeP	7	4.86 ± 0.505	53.86 ± 3.341	78.75 ± 3.829	3.87 ± 0.604	1.06 ± 0.075	2.66 ± 0.518	168.3 ± 23.21	62.09 ± 9.594	9.68 ± 2.564	8.32 ± 1.910
				P = 0.4871	P = 0.9867	P = 0.4429	P = 0.0355^*	P = 0.8692	P = 0.0180^*	P = 0.3311	P = 0.2189	P = 0.9519	P = 0.6776
	LTM	Control	7	5.17 ± 0.705	70.65 ± 4.122	66.92 ± 3.867	1.76 ± 0.155	0.77 ± 0.081	0.98 ± 0.098	202.8 ± 15.22	123.1 ± 7.946	5.72 ± 1.695	3.22 ± 0.628
		NeP	9	3.91 ± 0.500	62.23 ± 2.126	62.59 ± 2.602	2.51 ± 0.412	0.93 ± 0.092	1.58 ± 0.387	148.0 ± 13.37	89.84 ± 8.396	7.44 ± 1.463	4.14 ± 1.255
				P = 0.1548	P = 0.0727	P = 0.3519	P = 0.1472	P = 0.2291	P = 0.2091	P = 0.170^*	P = 0.0138^*	P = 0.4545	P = 0.5601
	Unresponsive	Control	3	3.21 ± 1.084	54.16 ± 4.564	75.26 ± 5.250	1.98 ± 0.262	0.88 ± 0.15	1.14 ± 0.205	195.5 ± 17.24	76.23 ± 21.145	8.54 ± 3.340	12.87 ± 3.639
		NeP	3	4.14 ± 1.472	53.28 ± 3.183	79.11 ± 5.968	2.71 ± 0.619	1.17 ± 0.06	2.77 ± 0.758	163.1 ± 26.37	74.371 ± 10.165	10.34 ± 3.344	13.3 ± 2.652
				P = 0.6365	P = 0.8704	P = 0.6449	P = 0.1616	P = 0.2445	P = 0.0834	P = 0.3204	P = 0.6313	P = 0.7617	P = 0.9266
Aβ	HTM	Control	26	12.42 ± 0.548	62.80 ± 2.280	75.18 ± 2.116	1.73 ± 0.061	0.71 ± 0.041	1.02 ± 0.032	262.9 ± 14.87	141.9 ± 9.230	9.39 ± 0.614	10.69 ± 1.551
		NeP	39	11.38 ± 0.504	63.21 ± 1.783	75.47 ± 1.674	2.45 ± 0.146	0.86 ± 0.054	1.58 ± 0.132	211.5 ± 11.07	94.47 ± 9.214	6.57 ± 0.765	8.98 ± 0.931
				P = 0.1794	P = 0.8863	P = 0.9127	P = 0.0003^***	P = 0.0492^*	P = 0.0012^**	P = 0.0281^*	P = 0.0118^*	P = 0.0101^*	P = 0.3184
	LTM (SKIN)	Control	50	17.02 ± 0.469	68.63 ± 1.100	63.09 ± 1.508	1.25 ± 0.038	0.49 ± 0.019	0.76 ± 0.028	262.4 ± 8.735	142.7 ± 4.855	5.51 ± 0.493	5.42 ± 0.834
		NeP	63	14.70 ± 0.548	65.63 ± 0.962	63.16 ± 1.292	1.48 ± 0.065	0.57 ± 0 019	0.90 ± 0.050	226.2 ± 7.947	131.7 ± 5.882	4.89 ± 0.365	5.65 ± 0.743
				P = 0.0023^**	P = 0.0423^*	P = 0.9704	P = 0.0046^*	P = 0.0027^**	P = 0.0222^*	P = 0.0027^**	P = 0.1641	P = 0.3045	P = 0.8398
	LT (MS)	Control	36	18.76 ± 0.638	66.47 ± 1.704	57.83 ± 0.929	0.96 ± 0.032	0.43 ± 0.017	0.53 ± 0.022	258.4 ± 12.44	186.0 ± 8.476	6.73 ± 0.678	1.58 ± 0.114
		NeP	53	16.69 ± 0.599	62.60 ± 1.055	56.63 ± 1.107	1.10 ± 0.045	0.49 ± 0.016	0.62 ± 0.033	225.9 ± 8.019	155.0 ± 5.126	7.07 ± 0.581	2.20 ± 0.146
				P = 0.0235^*	P = 0.0442^*	P = 0.4422	P = 0.0229^*	P = 0.0152^*	P = 0.0467^*	P = 0.0239^*	P = 0.0013^**	P = 0.7089	P = 0.0030^**
	Unresponsive	Control	8	12.67 ± 0.831	63.48 ± 2.774	81.95 ± 2.107	1.63 ± 0.062	0.63 ± 0.021	1.03 ± 0.048	258.4 ± 13.18	133.5 ± 7.025	8.34 ± 0.719	10.26 ± 3.545
		NeP	9	11.15 ± 1.088	61.03 ± 3.482	79.13 ± 3.438	2.29 ± 0.251	0.77 ± 0.093	1.53 ± 0.260	221.4 ± 23.38	104.8 ± 15.18	5.23 ± 1.207	9.74 ± 1.805
				P = 0.2922	P = 0.5966	P = 0.5083	P = 0.0297^*	P = 0.1891	P = 0.0948	P = 0.2023	P = 0.1270	P = 0.0487^*	P = 0.8933

Notes: Statistical tests for each variable were made in all subgroups comparing neurons in control and neuropathic rats. The means ± standard deviations of variables measured are given. The value of P (mean-Whitney) is shown below each section. The asterisks show the level of significance of the difference between neurons in control and neuropathic animals:

P < 0.05;

^**

P < 0.01;

^***

P < 0.001.

Abbreviations: n, the number of neurons in each group; CV, conduction velocity; Vm, resting membrane potential; APA, action potential amplitude; APdB, action potential duration at base; APRT, action potential rise time; APFT, action potential fall time; MRR, maximum rising rate; MFR, maximum falling rate; AHPA, afterhyperpolarization amplitude; AHP₅₀, afterhyperpolarization duration at 50% recovery; HTM, high threshold mechanoreceptive neurons; LTM, low threshold mechanoreceptive neurons; UN, unresponsive neurons; MS, muscle spindle neurons.