. 2012 Jun 27;5:217–225. doi: 10.2147/JPR.S33453

Table 2.

Results for SPI, TOpA, and I-SPI-TOpA through 24, 48, and 72 hours for study 1, study 2, and pooled dataset

Time period by dataset	Mean SPI/mm • hour (standard deviation)			Mean TOpA/mg IV morphine eq. (standard deviation)			I-SPI-TOpA

	Treatment	Control	P value	Treatment	Control	P value	P value
24 hours post time 0
Study 1	670 (401)	1191 (602)	<0.001^*	18.5^a (12.6)	24.6 (15.3)	0.123^a	0.013^*
Study 2	996 (504)	1270 (567)	0.080	20.6 (19.9)	36.9 (17.6)	0.004^*	0.005^*
Pooled^b	833	1231	<0.001^*	19.5	30.8	0.001^*	<0.0001^*
48 hours post time 0
Study 1	1351 (857)	2130 (1228)	0.012^*	30.6^a (19.9)	36.5 (25.5)	0.359^a	0.097
Study 2	2018 (1093)	2457 (1157)	0.178	36.3 (34.7)	56.4 (32.8)	0.042^*	0.039^*
Pooled^b	1684	2293	0.006^*	33.4	46.5	0.024^*	0.008^*
72 hours post time 0
Study 1	1864 (1239)	2838 (1807)	0.030^*	37.2^a (29.3)	44.9 (35.0)	0.396^a	0.136
Study 2	2842 (1722)	3485 (1807)	0.184	48.7 (46.1)	70.8 (44.3)	0.0940.078
Pooled^b	2337	3161	0.014^*	42.9	57.8	0.058	0.021^*

Notes:

Includes patient in the treatment group that reported taking morphine rescue medication as maximally allowed and not according to need for pain relief;

for the pooled data, least squared means are reported and are based on the analysis of variance model that included fixed effects for treatment, study/dose, and treatment-by-study interaction;

statistically significant (P ≤ 0.05).

Abbreviations: IV, intravenous; eq, equivalents; SPI, summed pain intensity; TOpA, total opioid analgesia; I-SPI-TOpA, integrated endpoint of summed pain intensity and total opioid analgesia.