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. 2012 Jun 20;5:151–167. doi: 10.2147/JPR.S32122

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© 2012 Meregalli et al, publisher and licensee Dove Medical Press Ltd

This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.

PMC Copyright notice

Results of nerve conduction velocity (NCV) study performed on the tail of control (CTRL) and bortezomib (BTZ)-treated rats: Experiment (Exp) 1, phase (A) 1 and (B) 2; Exp 2, phase (C) 1 and (D) 2; Exp 3, phase (E) 1 and (F) 2. BTZ induced a significant reduction in NCV in all BTZ-treated rats after 8 weeks of treatment and at the end of Exps 1, 2, and 3.^a The analgesic compounds tested did not significantly counteract the effect of BTZ on NCV.

Notes: ^aMean values plus or minus standard deviation; *Significantly different from CTRL (P < 0.001).

Abbreviations: BTZ-fu, bortezomib-fake-manipulated but untreated; Bupre, buprenorphine; CR4056 0.6, CR4056 at 0.6 mg/kg/day; CR4056 2, CR4056 at 2 mg/kg/day; CR4056 20, CR4056 at 20 mg/kg/day; CR4056 6, CR4056 at 6 mg/kg/day; CR4056 60, CR4056 at 60 mg/kg/day; Gaba, gabapentin; ws, weeks.