Table 2.
Proteins identified in OA synovial fluids in this study and in a previous proteomic study [10]
| Protein namea | Accession no.b | Scorec | % Coveraged | Number of peptidese |
|---|---|---|---|---|
| Transferrin | P02787 | 877.49 | 65 | 57 |
| α2-Macroglobulin | P01023 | 569.94 | 34 | 57 |
| Serum albumin | P02768 | 514.49 | 60 | 34 |
| Complement C3 | P01024 | 426.92 | 27 | 34 |
| Apolipoprotein A-I | P02647 | 405.32 | 67 | 26 |
| α1-Antitrypsin (α1 protease inhibitor) | P01009 | 388.37 | 66 | 27 |
| Apolipoprotein A-IV | P06727 | 370.16 | 60 | 27 |
| Haptoglobin | P00738 | 331.09 | 49 | 22 |
| Hemopexin (β-1B-glycoprotein) | P02790 | 273.36 | 40 | 20 |
| Gc-globulin (vitamin D-binding protein precursor) | P02774 | 269.18 | 43 | 21 |
| α1B-glycoprotein | P04217 | 215.74 | 47 | 16 |
| Complement factor B (C3/C5 convertase) | P00751 | 163.54 | 20 | 12 |
| α1-Antichymotrypsin | P01011 | 144.7 | 27 | 10 |
| Antithrombin-III | P01008 | 142.4 | 32 | 10 |
| Ceruloplasmin (EC 1.16.3.1) (Ferroxidase) | P00450 | 132.65 | 12 | 9 |
| Transthyretin | P02766 | 129.52 | 69 | 8 |
| Plasma protease C1 inhibitor | P05155 | 111.87 | 17 | 8 |
| Ig mu chain C region | P01871 | 98.51 | 16 | 7 |
| Actin, cytoplasmic 2 (γ-actin) | P63261 | 89.13 | 33 | 8 |
| Fibrinogen β chain | P02675 | 88.28 | 18 | 7 |
| α2-HS-glycoprotein | P02765 | 85.26 | 22 | 7 |
| Complement factor H (H factor 1) | P08603 | 80.47 | 8 | 8 |
| α1-Acid glycoprotein 1 (Orosomucoid-1) | P02763 | 68.98 | 23 | 5 |
| Complement C5 | P01031 | 55.88 | 8 | 7 |
| Prothrombin (coagulation factor II) | P00734 | 52.57 | 9 | 4 |
| Plasma retinol-binding protein | P02753 | 50.79 | 20 | 4 |
| Apolipoprotein E | P02649 | 49.32 | 21 | 4 |
| Afamin | P43652 | 48.67 | 7 | 4 |
| Fibrinogen α chain | P02671 | 48.63 | 6 | 4 |
| Gelsolin | P06396 | 47.03 | 4 | 3 |
| Complement C4 | P01028 | 39.34 | 8 | 6 |
| Vitronectin | P04004 | 38.1 | 6 | 3 |
| Apolipoprotein A-II | P02652 | 36.26 | 22 | 3 |
| Hemoglobin β subunit (Hemoglobin β chain) | P68871 | 31.88 | 17 | 2 |
| β2-Glycoprotein I (apolipoprotein H) | P02749 | 30.33 | 6 | 2 |
| Inter-α-trypsin inhibitor heavy chain H4 | Q14624 | 28.43 | 5 | 3 |
| Fibronectin | P02751 | 23.84 | 2 | 2 |
| Clusterin | P10909 | 21.17 | 12 | 2 |
| Complement component C8 γ chain | P07360 | 20.93 | 10 | 2 |
| Histidine-rich glycoprotein | P04196 | 20.11 | 5 | 2 |
| Fibrinogen γ chain | P02679 | 19.9 | 7 | 2 |
| Kininogen-1 | P01042 | 16.02 | 4 | 2 |
| Desmoplakin | P15924 | 11.59 | 1 | 2 |
| α1-Microglobulin/bikunin precursor protein precursor | P02760 | 11.13 | 9 | 2 |
aShown in bold are the proteins classified as plasma proteins (as assessed by www.HPRD.org). bUniProtKB/Swiss-Prot database. cAn aggregate score of the quality of the peptide spectra obtained, the total number of peptides identified, and percentage coverage of the protein. dThe number of amino acids identified as a percentage of the total number of amino acids in the corresponding protein. eThe number of peptides identified that correspond to the protein indicated.