Table 3.
Proteins newly identified in OA synovial fluids
| Protein namea | Accession no.b | Scorec | % Coveraged | No. of peptidese |
|---|---|---|---|---|
| Zinc-α2-glycoprotein | P25311 | 140.54 | 35 | 10 |
| Ig α1 chain C region | P01876 | 128.82 | 37 | 9 |
| Ig γ-1 chain C region | P01857 | 115.3 | 35 | 9 |
| Ig κ chain C region | P01834 | 87.06 | 85 | 6 |
| Calgranulin A (MRP-8) | P05109 | 67.87 | 33 | 5 |
| Collagen α1(I) chain | P02452 | 40.14 | 4 | 4 |
| Complement component C9 | P02748 | 36.76 | 9 | 4 |
| Serum paraoxonase/arylesterase 1 | P27169 | 34.77 | 13 | 3 |
| Ig κ chain V-III region SIE | P01620 | 33.65 | 38 | 3 |
| Ig heavy-chain V-III region BRO | P01766 | 28.94 | 24 | 2 |
| NF-κB-repressing factor | O15226 | 23.76 | 8 | 3 |
| A-kinase anchor protein-like protein 8 | Q9ULX6 | 23.65 | 11 | 3 |
| Structural maintenance of chromosomes 4-like 1 protein | Q9NTJ3 | 23.43 | 1 | 2 |
| Bromodomain adjacent to zinc-finger domain 2B (hWALp4) | Q9UIF8 | 22.6 | 3 | 3 |
| Histone deacetylase 5 | Q9UQL6 | 22.4 | 4 | 3 |
| Voltage-dependent R-type calcium channel α-1E subunit | Q15878 | 22.29 | 1 | 2 |
| Inhibitor of nuclear factor κB kinase β subunit | O14920 | 22.07 | 8 | 3 |
| β platelet-derived growth factor receptor precursor (EC 2.7.1.112) (CD140b antigen) | P09619 | 20.93 | 5 | 2 |
| Leucine-rich α2-glycoprotein | P02750 | 20.55 | 5 | 2 |
| Mitochondrial 28S ribosomal protein S29 | P51398 | 19.76 | 6 | 2 |
| Glucose-6-phosphate 1-dehydrogenase | P11413 | 19.58 | 14 | 3 |
| Collagen α2(I) chain | P08123 | 18.98 | 7 | 3 |
| Histone H4 | P62805 | 18.73 | 16 | 2 |
| Macrophage inflammatory protein 2-β | P19876 | 18.72 | 28 | 2 |
| Collagen α3(IV) chain | Q01955 | 18.15 | 5 | 2 |
| Histone-lysine N-methyltransferase, H3 lysine-9 specific 4 | Q15047 | 17.82 | 4 | 2 |
| Toll-like receptor 6 | Q9Y2C9 | 17.38 | 2 | 2 |
| Nuclear factor NF-κB p100 subunit | Q00653 | 17.22 | 7 | 2 |
| Possible global transcription activator SNF2L1 (SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1) | P28370 | 16.37 | 5 | 2 |
| RRP5 protein homologue | Q14690 | 16.35 | 3 | 2 |
| Interleukin-20 receptor α chain | Q9UHF4 | 16.22 | 11 | 2 |
| NF-κB inhibitor-like protein 1 | Q9UBC1 | 16.13 | 14 | 2 |
| Platelet endothelial cell-adhesion molecule | P16284 | 15.87 | 10 | 2 |
| Fibroblast growth factor receptor 2 | P21802 | 15.4 | 2 | 2 |
| Interleukin-1 receptor-associated kinase 1 | P51617 | 14.92 | 11 | 2 |
| Cadherin EGF LAG seven-pass G-type receptor 1 | Q9NYQ6 | 14.84 | 1 | 2 |
| Collagen α2(V) chain | P05997 | 14.78 | 5 | 2 |
| Zinc-finger A20 domain-containing protein 1 | Q6GQQ9 | 14.61 | 6 | 2 |
| Low-density lipoprotein receptor-related protein 1 (apolipoprotein E receptor) | Q07954 | 14.54 | 1 | 2 |
| Microtubule-actin crosslinking factor 1, isoforms 1/2/3/5 | Q9UPN3 | 14.53 | 1 | 2 |
| Zinc-finger DHHC domain-containing protein 13 | Q8IUH4 | 14.48 | 11 | 2 |
| Death-associated protein kinase 1 | P53355 | 14.41 | 3 | 2 |
| Collagen α1(V) chain | P20908 | 13.78 | 4 | 2 |
| Integrin α-V (Vitronectin receptor α subunit) | P06756 | 13.52 | 3 | 2 |
| Misshapen-like kinase 1(MAPK/ERK kinase kinase kinase 6) | Q8N4C8 | 13.36 | 4 | 2 |
| Cadherin EGF LAG seven-pass G-type receptor | Q9NYQ7 | 13.26 | 1 | 3 |
| Regulator of G-protein signaling 14 | O43566 | 13.21 | 8 | 2 |
| Collagen α1(VII) chain | Q02388 | 13.19 | 1 | 2 |
| Interleukin-12 receptor β2 chain | Q99665 | 13.1 | 5 | 2 |
| Interleukin-1β (IL-1β) | P01584 | 12.94 | 20 | 2 |
| Platelet-derived growth factor B chain | P01127 | 12.91 | 18 | 2 |
| Collagen α1(II) chain | P02458 | 12.65 | 6 | 2 |
| Pappalysin-1 | Q13219 | 12.58 | 2 | 2 |
| Complement C1q tumor necrosis factor-related protein 5 | Q9BXJ0 | 11.97 | 23 | 2 |
| Interleukin-18 receptor 1 precursor (IL-1 receptor-related protein) | Q13478 | 11.8 | 4 | 2 |
| A kinase anchor protein 10, mitochondrial (PRKA10) | O43572 | 11.36 | 8 | 2 |
| Neutrophil collagenase | P22894 | 11.34 | 9 | 2 |
| Protein-arginine deiminase type I | Q9ULC6 | 11.34 | 5 | 2 |
| TNF receptor-associated factor 5 (RING finger protein 84) | O00463 | 10.92 | 8 | 2 |
| Macrophage receptor MARCO | Q9UEW3 | 10.89 | 8 | 2 |
| Collagen α3(V) chain | P25940 | 10.32 | 1 | 2 |
| Histone acetyltransferase MYST3 | Q92794 | 10.14 | 2 | 2 |
| Leukocyte immunoglobulin-like receptor subfamily B member 4 | Q8NHJ6 | 9.43 | 11 | 2 |
| Mast/stem cell growth-factor receptor | P10721 | 9.3 | 5 | 2 |
aShown in bold are the proteins classified as plasma proteins (as assessed by www.HPRD.org). bUniProtKB/Swiss-Prot database. cAn aggregate score of the quality of the peptide spectra obtained, the total number of peptides identified, and percentage coverage of the protein. dThe number of amino acids identified as a percentage of the total number of amino acids in the corresponding protein. eThe number of peptides identified that correspond to the protein indicated.