Table 5.
Absolute and relative cytokine levels in healthy and OA serum, and in OA synovial fluid
| Cytokine | Normal serum levels (pg/ml)a | OA serum levels (pg/ml)b | OA SF levels (pg/ml)c | Ratio of OA serum levels to normal serum levels | Ratio of OA SF levels to OA serum levels |
|---|---|---|---|---|---|
| IL-6 | 3.02 (2.7-4.4) |
5.13 (4.4-5.8) |
975.39 (454.0-2,689.5) |
1.7 | 190.1 |
| IL-1β | 1.22 (1.0-1.3) |
1.58 (1.4-1.8) |
1.14 (1.0-1.7) |
1.3 | 0.7 |
| TNF | 0.00 (0.0-0.0) |
0.00 (0.0-0.0) |
2.92 (0.0-13.3) |
- | - |
| VEGF | 20.53 (11.7-65.6) |
78.22 (31.3-124.6) |
496.31 (245.0-577.8) |
3.8 | 6.3 |
| MCP-1 | 3.59 (0.0-11.9) |
18.53 (13.0-28.0) |
107.67 (84.8-191.1) |
5.2 | 5.8 |
| IP-10 | 537.00 (376.1-750.4) |
795.55 (684.7-1,029.7) |
2,105.40 (923.2-4,913.3) |
1.5 | 2.6 |
| MIG | 244.51 (173.5-374.6) |
420.13 (308.4-568.6) |
1,047.14 (389.8-1,925.3) |
1.7 | 2.5 |
OA, osteoarthritis; SF, synovial fluid; IL, interleukin; TNF, tumor necrosis factor; VEGF, vascular endothelial growth factor; MCP-1, macrophage chemotactic protein 1; IP-10, interferon γ-induced protein 10; MIG, monokine-induced by interferon γ. aThe median (IQR); n = 34 healthy individuals. bThe median (IQR); n = 23 individuals with OA. cThe median (IQR); n = 10 individuals with OA.