Table 1.
Baseline characteristics of participants in the AMIS Study (Number = 4,352)
| Aspirin group | Placebo group | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Total | Quartile 1 | Quartile 2 | Quartile 3 | Quartile 4 | Total | |
| sUA range, mg/dL men | 2.5-4.5 | 4.52-5.37 | 5.38-6.45 | 6.47-10.45 | 2.50-10.45 | 2.38-4.48 | 4.5-5.42 | 5.47-6.48 | 6.52-11.05 | 2.38-11.05 |
| women | 1.4-5.25 | 5.27-6.03 | 6.05-7 | 7.02-12.52 | 1.40-12.52 | 1.83-5.28 | 5.3-6.03 | 6.05-6.97 | 6.98-12.12 | 1.83-12.12 |
| Number | 543 | 541 | 541 | 544 | 2,169 | 547 | 539 | 551 | 546 | 2,183 |
| Mean sUA, mg/dL (SD) | 4.55 (0.57) |
5.55 (0.34) |
6.44 (0.34) |
8.05 (0.99) |
6.15 (1.43) |
4.59 (0.57) |
5.61 (0.3) |
6.43 (0.32) |
7.93 (0.91) |
6.14 (1.35) |
| Demographics | ||||||||||
| Age at first MI, years (SD) | 52.6 (8.0) |
52.5 (8.0) |
52.6 (8.3) |
52.8 (8.2) |
52.6 (8.1) |
53.0 (7.6) |
52.7 (8.1) |
52.5 (8.0) |
52.7 (7.9) |
52.7 (7.9) |
| Age at most recent MI, years (SD) | 53.1 (7.8) |
53.1 (7.9) |
53.1 (8.3) |
53.5 (8.0) |
53.2 (8.0) |
53.5 (7.6) |
53.1 (8.0) |
52.9 (7.9) |
53.4 (7.8) |
53.2 (7.8) |
| Age at randomization, years (SD) | 54.8 (8.0) |
54.8 (8.0) |
54.8 (8.4) |
55.1 (8.1) |
54.9 (8.1) |
55.2 (7.6) |
54.8 (8.1) |
54.5 (8.0) |
55.0 (7.9) |
54.9 (7.88) |
| Body mass index, kg/m2 (SD) | 24.8 (3.2) |
25.6 (3.3) |
26.1 (3.2) |
27.1 (3.7) |
25.9 (3.5) |
25.1 (3.1) |
25.6 (3.2) |
26.4 (3.4) |
26.8 (3.8) |
26.0 (3.5) |
| Men, % | 88.8 | 88.2 | 88.4 | 88.6 | 88.5 | 89.8 | 89.4 | 89.7 | 89.7 | 89.6 |
| African American, % | 5.7 | 4.3 | 6.7 | 9 | 6.4 | 7.1 | 5.9 | 3.1 | 7.5 | 5.9 |
| Physical examination data | ||||||||||
| Sedentary lifestyle, % | 16.7 | 16.3 | 17.4 | 21.3 | 17.9 | 16.8 | 15.6 | 15.4 | 20.9 | 17.2 |
| Alcohol usea, % | 88.4 | 84.7 | 82.1 | 82 | 84.3 | 88.1 | 84.6 | 85.3 | 80.6 | 84.7 |
| Smokerb, % | 40.7 | 40.1 | 31.8 | 29.6 | 35.5 | 39.9 | 37.3 | 31.2 | 32.8 | 35.3 |
| Heavy smokerc, % | 10.1 | 10.3 | 12.1 | 10 | 10.6 | 7.2 | 5.8 | 15.7 | 11.4 | 9.8 |
| Systolic blood pressure, mmHg (SD) | 126.4 (15.6) |
126.1 (15.4) |
129.0 (16.6) |
129.6 (16.5) |
127.8 (16.1) |
127.5 (17.1) | 127.1 (15.1) |
128.5 (15.5) |
129.5 (16.9) |
128.2 (16.2) |
| Diastolic blood pressure, mmHg (SD) | 78.3 (9.4) |
78.9 (8.9) |
79.6 (9.2) |
81.7 (9.8) |
79.6 (9.4) |
79.2 (9.3) |
78.9 (8.9) |
80.3 (9.4) |
81.9 (10.0) |
80.1 (9.5) |
| Laboratory data | ||||||||||
| Total glucose, mg/100 ml (SD) | 148.8 (56.8) |
155.4 (57.7) |
158.4 (50.1) | 171.2 (49.9) |
158.6 (54.3) |
159.1 (67.5) | 156.7 (53.3) |
160.1 (50.5) |
168.9 (52.2) |
161.2 (56.3) |
| Total cholesterol, mg/dL (SD) | 230.4 (44.7) |
235.7 (43.3) |
240.4 (43.2) | 243.2 (49.0) |
237.7 (45.5) |
234.0 (43.2) | 235.1 (42.4) | 240.2 (41.8) |
241.2 (42.5) |
237.7 (42.5) |
| Triglycerides, mg/dL (SD) | 160.7 (130.0) | 173.3 (101.6) |
190.6 (149.1) | 228.7 (192.2) | 189.9 (159.2) | 153.3 (86.2) |
162.7 (97.0) | 191.5 (116.6) | 230.1 (169.3) | 185.2 (125.7) |
| Comorbidities, % | ||||||||||
| Number of prior MI | ||||||||||
| 1 | 88.4 | 86.7 | 86.1 | 84.2 | 86.4 | 86.1 | 88.7 | 90.0 | 83.0 | 86.9 |
| 2 | 10.1 | 12.4 | 12.6 | 13.6 | 12.2 | 11.3 | 10.4 | 8.5 | 14.7 | 11.2 |
| ≥ 3 | 1.5 | 0.9 | 1.3 | 2.2 | 1.5 | 2.6 | 0.9 | 1.5 | 2.4 | 1.8 |
| History of diabetes | 13.4 | 8.1 | 9.2 | 8.8 | 9.9 | 17 | 10.4 | 7.8 | 10.1 | 11.3 |
| History of renal impairment | 4.2 | 4.6 | 5.2 | 6.6 | 5.2 | 3.7 | 4.3 | 4.9 | 6.8 | 4.9 |
| Gout flaresd | 3.1 | 4.4 | 4.3 | 8.3 | 5.0 | 3.5 | 2.2 | 4.5 | 7.3 | 4.4 |
| Medications, % | ||||||||||
| Gout medicationsd, e | 4.2 | 4.1 | 3.1 | 5.0 | 4.1 | 3.3 | 2.0 | 4.5 | 4.8 | 3.7 |
| Non-aspirin NSAIDs | 1.5 | 1.7 | 0.4 | 1.8 | 1.3 | 0.7 | 0.9 | 0.9 | 1.3 | 1.0 |
| Anti-diabetic medications | 7.9 | 2.8 | 3.5 | 3.3 | 4.4 | 8.0 | 4.8 | 3.4 | 5.7 | 5.5 |
| Blood pressure medications | 5.7 | 8.3 | 8.9 | 18.4 | 10.3 | 6.4 | 7.8 | 8.5 | 16.7 | 9.8 |
| Lipid-lowering medications | 5.3 | 5.7 | 4.6 | 4.6 | 5.1 | 4.9 | 3.9 | 5.4 | 3.8 | 4.5 |
| Follow-up time, years (SD)f | 2.9 (0.5) |
2.9 (0.5) |
2.8 (0.5) |
2.8 (0.5) |
2.8 (0.5) |
2.8 (0.5) |
2.8 (0.5) |
2.9 (0.5) |
2.8 (0.6) |
2.8 (0.5) |
| Minimum (years) | 1.0 | 0.9 | 0.9 | 0.9 | 0.9 | 0.90 | 0.90 | 0.8 | 0.9 | 0.8 |
| Maximum (years) | 3.2 | 3.2 | 3.2 | 3.2 | 3.2 | 3.2 | 3.2 | 3.2 | 3.1 | 3.2 |
a < 1.5 oz/day; bIncludes cigarettes, pipes, and cigars; c > 45 cigarettes/day; dGout flares and medications determined at baseline; eIncludes probenecid, allopurinol, and colchicine; fFollow up from baseline to last observation. Mean (standard deviation) is provided unless specified otherwise. AMIS, Aspirin Myocardial infarction study; MI, myocardial infarction; NSAID, non-steroidal anti-inflammatory drug; sUA, serum urate; SD, standard deviation.