Table 3.
AS patients with normal pulmonary function versus patients with restrictive pattern
| Normal pulmonary function (n = 105) | Restrictive pattern (n = 27) | P-value | |
|---|---|---|---|
| Age (yr), median (min, max) | 46 (30,70) | 57 (33,68) | 0.015 |
| Males, n (%) | 66 (63) | 21 (78) | 0.218 |
| Disease duration (yr) | 22 (7,55) | 27 (8,46) | 0.054 |
| Lifelong non-smokers, n (%) | 53 (51) | 15 (56) | 0.799 |
| FVC (liters), mean (SD) | 4.3 (1.1) | 2.8 (0.7) | < 0.001 |
| FVC % | 103.4 (12.8) | 69.4 (6.6) | < 0.001 |
| FEV1 (liters) | 3.4 (0.9) | 2.2 (0.5) | < 0.001 |
| FEV1 % | 96.6 (12.2) | 68.6 (7.9) | < 0.001 |
| PEF (liters/minute) | 493.2 (119.9) | 400.0 (101.3) | < 0.001 |
| PEF % | 100.0 (16.0) | 85.5 (15.8) | < 0.001 |
| FEV1/FVC % | 77.4 (6.1) | 79.4 (8.3) | 0.158 |
| ASDAS | 2.8 (1.0) | 3.1 (0.9) | 0.140 |
| BASDAI | 4.1 (2.1) | 4.3 (2.0) | 0.709 |
| BASFI | 1.8 (0.8, 8.0) | 2.9 (0.9, 10.0) | 0.003 |
| BASMI | 2.9 (1.6) | 5.4 (1.8) | < 0.001 |
| Chest expansion (cm) | 4.6 (2.1) | 2.9 (1.8) | < 0.001 |
| Lumbar flexion (cm) | 4.3 (1.4) | 2.4 (1.6) | < 0.001 |
| Lumbar lateral flexion (cm) | 14.4 (5.6) | 7.6 (5.5) | < 0.001 |
| TWD (cm) | 11.8 (7.8, 43.5) | 18.5 (10.5, 38.0) | < 0.001 |
| CRP | 3.0 (1.0, 57.0) | 7.0 (1.0, 28.0) | 0.063 |
| ESR | 15.0 (2.0, 83.0) | 28.0 (1.0, 90.0) | 0.006 |
| VO2peak | 41.0 (7.2) | 35.9 (8.9) | 0.002 |
| Anti-TNF-α-medication, n (%) | 21 (20) | 9 (33) | 0.201 |
PFT results, clinical and laboratory measures in the AS patients (n = 132).
Mann Whitney U test for comparisons of skewed distributions, Independent Sample T-test for normally distributed data. FEV1%, FVC% and PEF% are adjusted for age, gender and actual height. FEV1/FVC % = absolute FEV1/FVC ratio. The other measurements are not adjusted. Chi-Square test for comparisons of categorical data