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. 2012 Jan 27;14(1):R22. doi: 10.1186/ar3704

Table 2.

Results derived from multivariable Cox regression modelsa

Model A: No medications included Model B: Corticosteroid included Model C: AZA/MTX included

HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Sex (male referent) 0.14 (0.04 to 0.58) 0.006 0.10 (0.01 to 1.27) 0.076 0.09 (0.02 to 0.52) 0.007
Age at diagnosis (years) 1.07 (1.04 to 1.11) 0.000 1.06 (1.01 to 1.12) 0.018 1.11 (1.06 to 1.16) 0.000
Race (white referent)
 Black 3.94 (1.48 to 10.46) 0.006 1.5 (0.3 to 7.4) 0.61 9.5 (2.42 to 37.09) 0.001
 Other or unknown 2.03 (0.66 to 6.29) 0.22 0.86 (0.19 to 4.0) 0.85 5.6 (1.3 to 24.3) 0.021
Diagnosis (PM referent) 0.78 (0.24 to 2.54) 0.681 1.14 (0.26 to 5.1) 0.86 0.30 (0.1 to 1.5) 0.141
Sex-diagnosis interaction 6.41 (1.22 to 33.7) 0.028 12.5 (0.65 to 241.5) 0.10 15.7 (1.9 to 128.0) 0.010
IV corticosteroid (vs oral) - - 5.6 (1.6 to 20.3)b 0.008 - -
MTX (vs AZA) - - - - 0.96 (0.3 to 2.8) 0.938

aAZA = azathioprine; CK = creatine kinase; IIM = idiopathic inflammatory myopathy; ILD = interstitial lung disease; IV = intravenous; MTX = methotrexate; PM = polymyositis. bSteroid association was restricted to the white subset of the study population when stratified models were used. Inclusion of initial CK level, comorbid ILD or cancer (ever or within 3 years of IIM diagnosis) in additional models did not substantively affect results.