. 2012 Feb 7;14(1):R33. doi: 10.1186/ar3738

Table 2.

Renal parameters, immunoglobulin (Ig)A, IgG and IgM levels, and IgG course, Days-14 to 14

Patient #	Screening day (Day -14)*			Day 1						Day 14

	GFR	UPr:Cr	IgG	GFR	UPr:Cr	IgA	IgM	IgG	IgG change from Day -14	GFR	UPr:Cr	IgA	IgM	IgG	IgG change from Day 1

	(ml/min/1.73 m²)	(mg/mg)	(g/l)	(ml/min/1.73 m²)	(mg/mg)	(g/l)	(g/l)	(g/l)		(ml/min/1.73 m²)	(mg/mg)	(g/l)	(g/l)	(g/l)	(%)
2	73.5^L	1.6	16.3	68.4^L	0.2	1.9	1.0	16.3	0	45.3^{L1, a}	0.1^a	2.0^a	0.8^a	15.1^a	-7.4
8	78.7	2.3	14.2	76.3	N/A	2.9	0.3^L	13.9	-2.1	88.8^a	0.8^a	2.7^a	0.3^{L, a}	11.1^a	-20.1
3	73.4^L	8.2	16.3	81.6	5.6	4.5	1.2	13.0	-20.3	72.2^L	8.1^a	2.3^a	0.7^a	6.5^a	-49.7
5	74.5^L	3.0	20.1	89.0	1.0	6.3	1.2	14.3	-28.9	69.7^{L, b}	7.1	5.4^b	1.1^b	10.9^b	-23.8
13	33.6^L2	4.6	11.3	30.9^L2	12.4	1.1	0.3^L	4.9^L	-56.9	34.1^{L2, a}	8.4^a	0.6^{L, a}	< 0.2^L	3.6^{L, a}	-25.5
14	26.9^c,†^{, L2}	12.0	9.1	24.4^L2	18.0	< 0.3^L	< 0.2^L	4.8^L	-47.1	38.8^{L2, d}	9.0^d	0.5^{L, d}	0.6^d	2.5^{L, d}	-47.4

Patients #2 and #8 randomized to placebo; Patients #3, #5, #13 and #14 randomized to atacicept 150 mg subcutaneously twice weekly (4 weeks), then 150 mg weekly (48 weeks). *IgA and IgM levels not recorded at screening; GFR, glomerular filtration rate; Ig, immunoglobulin; UPr:Cr, urine protein:creatinine ratio.

Values > ULN indicated in italics; ^LValues < LLN with (Grade 1 to 4), where applicable; Ig reference ranges: IgA, 0.7 to 4.0 g/l; IgM, 0.4 to 2.3 g/l; IgG, 5.7 to 17.6 g/l. ^aMeasured Day 15; ^bMeasured Day 13; ^cMeasured Day -18; ^dMeasured Day 18. †GFR > 30 ml/min/1.73 m²on repeat testing.