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. Author manuscript; available in PMC: 2012 Jul 10.
Published in final edited form as: J Nat Prod. 2007 Feb 14;70(4):589–595. doi: 10.1021/np060535r

Figure 3.

Figure 3

Provided that the chemical shift dispersion is sufficient, the proposed qHNMR experiment can routinely detect and quantitate minor impurities with a dynamic range of 300:1 or better. This example demonstrates the relative intensities of the signals of the impurities i-2 (5.68%) and i-4 (0.25%) and their relationship with the main resonances of the 84.8% pure taxol sample B. The remarkable 400:1 dynamic range between taxol and its impurity i-4 also visualizes how readily the signals of minor impurities can be overlooked and/or buried under noise unless NMR spectra are acquired with adequate S/N.