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Summary of High-Throughput Screen for Tissue-Nonspecific Alkaline Phosphatase with the Luminescent Assay.
| Compounds Screened | Hits Identified | Hit Criteria | Hit Rate (%) | |
|---|---|---|---|---|
| Primary HTS | 64,394 | 73 | >50% Inhibition | 0.11 |
| Duplicate single-concentration confirmation | 73 | 55 | >50% Inhibition | 75.3 |
| Dose-response confirmation | 55 | 53 | IC50 < 20 µM | 96.4 |
