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. 2010 Apr 27;15(5):3010–3037. doi: 10.3390/molecules15053010

Table 5.

SAR of the bisarylsulfonamide series.

graphic file with name molecules-15-03010-i015.jpg

Compound No. R1 R2 R3 W X Y Z TNAP-Lumi IC50 (µM)
CID-2931238 CH3O H CH3O SO2 NH N CH 0.25
MLS-0068486 CH3O H CH3O SO2 NH N No ring 0.92
MLS-0090845 H H H SO2 NH N CH NA
MLS-0090844 CH3O H H SO2 NH N CH 25.7
MLS-0090842 CH3O CH3O H SO2 NH N CH NA
MLS-0111875 CH3O H CH3O SO2 NH N CH 19.5
MLS-0111667 CH3O H CH3O CH2 NH N CH NA
MLS-0111668 CH3O H CH3O NH CH2 N CH NA
MLS-0111666 CH3O H CH3O CO NH N CH NA
MLS-0111639 CH3O H CH3O SO2 NH CH N NA