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. 2012 Mar 20;20(7):1327–1337. doi: 10.1038/mt.2012.28

Figure 6.

Figure 6

Overexpression of GRP78/BiP protein in the substantia nigra pars compacta (SNc) of Parkinson disease (PD) rats leads to reprogramming the endoplasmic reticulum (ER) stress signaling. At 4 weeks of PD progression GRP78/BiP significantly reduced accumulation of the ER stress hallmarks such as cleaved pATF6 (pATF6 50) and ATF4 (PERK pathway). Production of C/EBP homologous protein (CHOP) protein was also down regulated at 4 and 8 weeks in rat SNc injected with both α-synuclein (α-syn) and GRP78/BiP compared to SNc of rats injected with α-syn. Injection with recombinant adeno-associated virus (rAAV) BiP was not a statistically different from green fluorescent protein (GFP) injection or intact control. Tukey's post hoc results are indicated as *, **, ***P < 0.05, 0.01, and 0.001, respectively versus α-syn; #P < 0.05 versus α-syn + GRP78/BiP; n = 4–7 for each group.