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. 2012 Apr 3;20(7):1360–1366. doi: 10.1038/mt.2012.62

Figure 3.

Figure 3

Temporal and spatial distribution of human erythropoietin (hEPO) mRNA expression after polyplex injection. Sprague-Dawley (SD) rats (n ≥ 4) were intravenously injected with either 200 µg phEPO/ABP at wt/wt ratio 1/10 or 200 µg phEPO/PEI at wt/wt ratio 1/1. We evaluated the in vivo expression level of hEPO mRNA using real-time quantitative reverse transcriptase (RT)-PCR at the indicated times in organs after injection of the polyplexes. Error bars represent SEM with n = 5–10 per group. *P < 0.05, **P < 0.01, and ***P < 0.001 compared with phEPO/PEI (dashed line as 100%).