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Schematic of anchoring of collagen Q (ColQ) to neuromuscular junction (NMJ). Twelve catalytic subunits of acetylcholinesterase (AChE) are attached to ColQ to form ColQ-tailed AChE. Two heparan sulfate proteoglycan-binding domains of ColQ are bound to perlecan. C-terminal domain of ColQ is bound to muscle-specific kinase (MuSK). Nerve-derived agrin binds to an LRP4–MuSK complex and induces rapsyn-mediated clustering of acetylcholine receptors (AChR) by phosphorylating AChR.
