Figure 12.

Changes in the size of the ovary and its follicles. (A) Bar graph depicting the changes in ovarian volume with age in wild-type (WT) mice (white bars) and premutation (PM) mice (black bars). Bars with different letters are significant at p<0.05 by analysis of variance (ANOVA) followed by t-test post hoc. (B) Antral follicle area in four-month-old WT and PM mice (ANOVA, p<0.003). Antral follicle areas were measured at each follicle’s maximal diameter. (C) Granulosa cell (GC) number in these follicles (ANOVA, p<0.002). (D) The relationship between antral follicle area and GC number. Values for WT mice are represented by black dots; values for PM mice are represented by red dots.