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Coronal abnormalities and premature loss of prophase I arrest in wild-type (WT) and premutation (PM) mice. (A) Hematoxylin and eosin (H&E) staining of a follicle from a four-month-old WT mouse shows a normal graafian follicle. Bar = 100 µm. (B) PM follicle with a partial corona (insert) or absent corona typical of atresia. Bar = 100 µm. (C) Example of a PM antral follicle with an incomplete corona that has a spindle and chromosomes in anaphase.
