Table 2.
Effects of 5-HT2B receptor antagonist SB204741 on 10 Hz EA anti-hyperalgesia in rats with CFA-induced hind paw inflammation (n=6–8). *P<0.05 vs sham+DMSO
| Groups | Baseline (s) |
After EA or sham (s) |
||
|---|---|---|---|---|
| Ipsilateral | Contralateral | Ipsilateral | Contralateral | |
| EA+14 nmol of SB204741 | 10.14 (0.19) | 9.59 (0.24) | 6.86 (0.31)* | 10.01 (0.29) |
| EA+70 nmol of SB204741 | 9.64 (0.67) | 9.89 (0.45) | 7.89 (0.89)* | 10.14 (0.54) |
| Sham EA+70 nmol of SB204741 | 9.87 (0.42) | 10.05 (0.45) | 5.20 (0.42) | 9.89 (0.56) |
| EA+DMSO | 9.87 (0.35) | 10.23 (0.46) | 7.20 (0.46)* | 10.34 (0.52) |
| Sham+DMSO | 9.82 (0.38) | 9.97 (0.35) | 5.20 (0.43) | 10.43 (0.60) |