Table 3.
Effects of 5-HT3 receptor antagonist LY278584 on 10 Hz EA anti-hyperalgesia in rats with CFA-induced hind paw inflammation (n=6–8). *P<0.05 vs sham +saline
| Groups | Baseline |
After EA or sham (s) |
||
|---|---|---|---|---|
| Ipsilateral | Contralateral | Ipsilateral | Contralateral | |
| EA+10 nmol of LY278584 | 9.74 (0.35) | 9.84 (0.29) | 6.79 (0.22)* | 10.29 (0.55) |
| EA+48 nmol of LY278584 | 9.70 (0.47) | 10.20 (0.42) | 7.9 (0.83)* | 10.25 (0.38) |
| Sham EA+48 nmol of LY278584 | 9.60 (0.58) | 9.87 (0.41) | 5.23 (0.54) | 9.95 (0.43) |
| EA+saline | 9.95 (0.60) | 10.16 (0.43) | 7.06 (0.48)* | 10.51 (0.60) |
| Sham+saline | 10.20 (0.50) | 9.84 (0.38) | 5.30 (0.40) | 10.23 (0.50) |