Table 4.
Effects of 5-HT1AR antagonists NAN-190 hydrobromide and WAY-100635 maleate salt on 10 Hz EA anti-hyperalgesia in rats with CFA-induced hind paw inflammation (n=6–8). *P<0.05 vs sham + DMSO
| Groups | Baseline (s) |
After EA or sham (s) |
||
|---|---|---|---|---|
| Ipsilateral | Contralateral | Ipsilateral | Contralateral | |
| EA+8 nmol of NAN-190 hydrobromide | 9.51 (0.33) | 10.29 (0.35) | 6.96 (0.23)* | 10.37 (0.38) |
| EA+42 nmol of NAN-190 hydrobromide | 10.28 (0.60) | 10.03 (0.50) | 5.52 (0.54) | 9.95 (0.47) |
| Sham EA+42 nmol of NAN-190 hydrobromide | 10.20 (0.35) | 10.32 (0.52) | 5.30 (0.34) | 9.98 (0.49) |
| EA+DMSO | 9.87 (0.35) | 10.23 (0.46) | 7.20 (0.46)* | 10.34 (0.52) |
| Sham+DMSO | 9.82 (0.38) | 9.97 (0.35) | 5.20 (0.43) | 10.43 (0.60) |
| EA+8 nmol of WAY-100635 maleate salt | 9.66 (0.38) | 9.69 (0.31) | 5.75 (0.28) | 9.70 (0.20) |
| EA+42 nmol of WAY-100635 maleate salt | 9. 49 (0.37) | 9.70 (0.41) | 5.22 (0.38) | 10.17 (0.49) |
| Sham EA+42 nmol of WAY-100635 maleate salt | 9.85 (0.41) | 10.05 (0.52) | 5.60 (0.35) | 9.98 (0.43) |