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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Cancer Res. 2012 Apr 17;72(12):3048–3059. doi: 10.1158/0008-5472.CAN-11-3649

Figure 1. Comparison of BRAFV600E and KRASG12D initiated lung tumorigenesis.

Figure 1

A: H&E staining of lung sections from BRafCA/+ or KRasLSL/+ mice 6 (top panels) or 17 (middle panels) weeks after intranasal infection with 107 pfu Ad-Cre. Scale bar represents 500μm. H&E staining of lung tumors observed in BRafCA/+ and KRasLSL/+ illustrate divergent tumor phenotypes at 17 weeks after Ad-Cre initiation (bottom panels). Bar represents 50μm. Images are 40× magnification.

B: Tumor number and size were quantified for BRAFV600E or KRASG12D-induced lung tumors at 6 weeks. Percent tumor burden was calculated as tumor area per total lung section area at 6 or 17 weeks.

C: Classification of tumor types observed in BRafCA/+ and KRasLSL/+ mice at 17 weeks post infection with Ad-Cre.