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. Author manuscript; available in PMC: 2013 Jun 15.
Published in final edited form as: Cancer Res. 2012 Apr 17;72(12):3048–3059. doi: 10.1158/0008-5472.CAN-11-3649

Figure 4. BRAFV600Eand KRASG12Ddriven lung tumors express the Alveolar Type 1 pneumocyte marker Aquaporin 5 (AQP5).

Figure 4

A: Immunofluorescent staining of BRAFV600E and KRASG12D driven lung tumors using antibodies against Surfactant Protein C (SP-C, red) and Aquaporin 5 (AQP5, green).

B: Electron microscopy image of a BRAFV600E-driven lung tumor demonstrating AT2-like cells with prominent lamellar body (red arrow). Bar represents 2μm.

C: BRAFV600E- driven tumors from mice either wild type or null for AQP5 stained with anti-AQP5 antiserum.