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. Author manuscript; available in PMC: 2012 Jul 10.
Published in final edited form as: Mol Cancer Ther. 2009 Jun 9;8(6):1589–1595. doi: 10.1158/1535-7163.MCT-09-0038

Figure 4.

Figure 4

Mitotic catastrophe results of MDA-MB-231-BR cells. Gray columns, vehicle-treated cells; white columns, cells treated with vorinostat (1 µmol/L) alone; black columns, cells treated with irradiation alone (2 Gy); hatched columns, cells treated with the combination of vorinostat (1 µmol/L) and irradiation (2 Gy). Vorinostat was given 16 h before treatment and maintained in the medium until cells were collected at designated time points. Columns, mean; bars, SE. Nuclear fragmentation was defined as the presence of two or more distinct lobes within a single cell. *, P < 0.01, according to Student's t test (irradiation versus vorinostat + irradiation).