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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Cell Signal. 2011 Nov 18;24(3):794–802. doi: 10.1016/j.cellsig.2011.11.014

Figure 3. Sequences in the C-terminus of the α1A- and α1B-Subtypes Drive Nuclear Localization in Adult Cardiac Myocytes.

Figure 3

(A) Amino acid schematic diagram of the α1A- and α1B-ARs. Lysine (K) and arginine (R) residues mutated to alanine within the nuclear localization sequence for each receptor are indicated in red. Amino acid residues critical for ligand binding are indicated in black and regions for Gαq binding are indicated in blue [33–35]. (B) Representative confocal images of the α1A-WT (left) and the α1A-NLSmut (right) adrenergic receptors expressed in α1ABKO cardiac myocytes (n=6 separate cultures). (C) Representative confocal images of the α1B-WT (left) and α1B-NLSmut (right) adrenergic receptors express in α1ABKO cardiac myocytes (n=6 separate cultures).

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