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. Author manuscript; available in PMC: 2013 Mar 1.
Published in final edited form as: Cell Signal. 2011 Nov 18;24(3):794–802. doi: 10.1016/j.cellsig.2011.11.014

Figure 4. Nuclear Localization is Required for α1-AR Signaling in Adult Cardiac Myocytes.

Figure 4

Representative Western blot for phosphorylated ERK (P-ERK) and total ERK (T-ERK) from α1ABKO cardiac myocytes expressing (A) α1A-wild-type or α1A-NLSmut or (B) α1B-wild-type or α1B-NLSmut treated with 20 µM phenylephrine (PE) for 20 minutes (n=3). (C) Representative Western blot for P-ERK and T-ERK in wild-type cardiac myocytes treated with 20 µM PE for 20 minutes in the absence or presence of the nuclear export inhibitor leptomycin B (lepB) (n=6).

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