TABLE 3.
Biological process, molecular function, and pathway categories with methylated genesa
| Total | Hypermethyl aton |
Hypermet hylaton (expected) |
p-value | |
|---|---|---|---|---|
| Biological process | ||||
| Signal transduction | 1560 | 188 | 99.8 | 1.29E-17 |
| Developmental processes | 1157 | 148 | 74.0 | 2.62E-15 |
| Neuronal activities | 299 | 64 | 19.1 | 2.91E-15 |
| Cell communication | 539 | 91 | 34.5 | 7.33E-15 |
| Cell surface receptor mediated signal transduction | 686 | 100 | 43.9 | 1.94E-12 |
| Ectoderm development | 390 | 70 | 25.0 | 2.61E-12 |
| Neurogenesis | 360 | 64 | 23.0 | 7.94E-11 |
| Cell adhesion | 257 | 49 | 16.4 | 8.06E-10 |
| mRNA transcription regulation | 841 | 104 | 53.8 | 1.41E-08 |
| Cell adhesion-mediated signaling | 152 | 35 | 9.7 | 3.36E-08 |
| G-protein mediated signaling | 307 | 52 | 19.6 | 7.79E-08 |
| Protein metabolism and modification | 1506 | 55 | 96.3 | 1.77E-05 |
| mRNA transcription | 1080 | 112 | 69.1 | 2.89E-05 |
| Biological process unclassified | 2877 | 133 | 184.0 | 5.50E-05 |
| Synaptic transmission | 147 | 26 | 9.4 | 7.18E-04 |
| Cell proliferation and differentiation | 586 | 62 | 37.5 | 2.66E-03 |
| Sensory perception | 139 | 21 | 8.9 | 1.03E-02 |
| Ion transport | 278 | 36 | 17.8 | 1.04E-02 |
| Electron transport | 120 | 0 | 7.7 | 1.37E-02 |
| Cation transport | 226 | 31 | 14.5 | 1.64E-02 |
| Other neuronal activity | 84 | 16 | 5.4 | 2.04E-02 |
| Other metabolism | 308 | 7 | 19.7 | 2.54E-02 |
| Mesoderm development | 293 | 36 | 18.7 | 2.84E-02 |
| Pre-mRNA processing | 166 | 1 | 10.6 | 3.80E-02 |
| Nerve-nerve synaptic transmission | 38 | 10 | 2.4 | 4.21E-02 |
| Action potential propagation | 9 | 5 | 0.6 | 4.68E-02 |
| Molecular function | ||||
| Receptor | 553 | 97 | 35.4 | 9.24E-18 |
| G-protein coupled receptor | 146 | 36 | 9.3 | 2.33E-09 |
| Cell adhesion molecule | 150 | 34 | 9.6 | 1.34E-08 |
| Homeobox transcription factor | 142 | 34 | 9.1 | 1.85E-08 |
| Transcription factor | 1118 | 124 | 71.5 | 2.03E-08 |
| Extracellular matrix | 144 | 32 | 9.2 | 7.00E-08 |
| Cadherin | 39 | 17 | 2.5 | 2.04E-07 |
| Ion channel | 164 | 31 | 10.5 | 4.44E-06 |
| HMG box transcription factor | 18 | 9 | 1.2 | 5.37E-04 |
| Molecular function unclassified | 2736 | 131 | 175.0 | 7.78E-04 |
| Ligase | 231 | 2 | 14.8 | 1.20E-03 |
| Voltage-gated ion channel | 76 | 16 | 4.9 | 7.27E-03 |
| Ligand-gated ion channel | 41 | 11 | 2.6 | 1.42E-02 |
| Basic helix-loop-helix transcription factor | 71 | 14 | 4.5 | 4.12E-02 |
| Pathway | ||||
| Cadherin signaling pathway | 88 | 20 | 5.6 | 2.86E-04 |
a
Gene ontology analysis was performed using the PANTHER Classification System.