TABLE 4.

Assessment of promoter hypermethylation in “CAN genes”^a

CAN gene	p-value	Δβ(mean)	β(mean)_normal	β(mean)_tumor
ABCA1	7.40E-01	−0.001	0.023	0.024
ACSL5	1.37E-07	0.265	0.854	0.589
ADAMTS15	1.45E-01	−0.005	0.031	0.036
ADAMTS18	6.86E-01	0.014	0.252	0.238
APC	1.01E-01	−0.042	0.037	0.080
CD109	3.18E-02	−0.040	0.045	0.085
CHL1	5.74E-08	−0.270	0.169	0.440
CNTN4	4.61E-02	−0.062	0.256	0.318
CSMD3	2.21E-04	−0.156	0.070	0.227
EPHA3	1.25E-01	−0.041	0.188	0.229
EPHB6	1.14E-01	−0.011	0.018	0.029
ERCC6	3.06E-01	−0.003	0.019	0.022
EYA4	1.70E-11	−0.510	0.035	0.545
FBXW7	1.44E-01	0.006	0.084	0.078
GALNS	8.73E-01	0.000	0.029	0.029
GNAS	7.05E-01	−0.012	0.526	0.538
GUCY1A2	4.09E-04	−0.218	0.123	0.341
KCNQ5	8.24E-12	−0.491	0.037	0.528
KRAS	1.83E-01	−0.007	0.021	0.028
LRP2	4.60E-03	−0.098	0.082	0.180
MAP2	1.23E-03	−0.104	0.379	0.483
MLL3	4.09E-02	−0.028	0.073	0.101
MMP2	1.61E-08	−0.286	0.214	0.500
NF1	2.57E-01	0.007	0.079	0.073
PHIP	3.39E-01	−0.002	0.035	0.037
PKNOX1	8.50E-01	0.000	0.048	0.047
PRKD1	2.31E-01	−0.063	0.300	0.364
PTPRU	8.11E-05	0.018	0.051	0.033
RET	1.39E-02	−0.107	0.075	0.182
SCN3B	3.43E-01	−0.031	0.094	0.126
SFRS6	5.15E-02	−0.004	0.028	0.031
SLC29A1	2.49E-01	0.003	0.055	0.052
SMAD4	5.40E-02	−0.003	0.027	0.031
TCF7L2	7.88E-01	−0.001	0.053	0.054
TGFBR2	2.84E-02	−0.012	0.026	0.038
UHRF2	1.46E-01	−0.003	0.036	0.039
UQCRC2	4.59E-02	−0.007	0.031	0.038

^a“CAN genes” are candidate colorectal cancer genes described by Sjoblom et al³⁴.