Fig. 3.

Ex-RAD pretreatment enhances recovery of peripheral blood cells in irradiated C3H mice. Effect of Ex-RAD on (a) total white blood cells (WBC), (b) absolute neutrophil count (ANC), (c) monocytes (MONO) and (d) platelets (PLT) in mice (n = 10 per group) subjected to total-body gamma radiation with a sublethal dose of 6 Gy (0.6 Gy/min) was measured. Mice were administered sc injection of vehicle (1% Tween-80, 0.1 M KP buffer, 15 mM NaCl, pH 8.2) or Ex-RAD 500 mg/kg body weight, 24 h and 15 min prior to gamma radiation. Day 0 represents the day of irradiation. Data represented are means ± standard error of the mean (SEM) for n = 10 mice for each time point. The marked group (*) indicates significant difference (P < 0.05) between irradiated Ex-RAD compared with irradiated vehicle group by Tukey–Kramer method. Note: Some error bars are very small and hence not visible in the figure.