Table 1.

Summary of tumor incidence in the lungs of K-ras^LA1 mice

Group	No. of mice	No. of tumors/mouse			Adenocarcinoma	Adenomaf
		Total	>1 mm	<1 mm		++ +	++	+
Control	5	17.36 ± 3.04	5.89 ± 3.57	11.64 ± 0.70	3	2	0	0
Radiation only	5	16.44 ± 2.71	5.28 ± 2.72	10.92 ± 3.83	2	0	1	2
Beclin1 only	5	11.19 ± 1.21a,c	3.28 ± 0.98	7.94 ± 1.51	1	1	2	0
Radiation + Beclin1	5	8.97 ± 0.56b,d,e	2.92 ± 1.10	6.06 ± 1.61b	0	0	0	2

Sixteen K-ras^LA1 lung cancer model mice were randomly divided into four groups; control, radiation only, beclin1 only and radiation/beclin 1 combination. Animals were 17 weeks old at sacrifice. Lungs were collected, tumor numbers/sizes on the surface of lungs were counted, and fixed in 10% neutral buffered formalin for histological examination. Incidence and multiplicity of lung proliferative lesions were compared (mean ± SE).

^aP < 0.05 compared with control group; ^bP < 0.01 compared with control group; ^cP < 0.05 compared with radiation only group; ^dP < 0.01 compared with radiation only group; ^eP < 0.05 compared with beclin1 only group; ^fgrades of adenoma: ++ + , severe; ++ , moderate; +, mild.