Fig 5.
IgH gene features of IgM memory B cells. (a) Analysis of antibodies from IgM memory B cells, including the VH gene repertoire in 6 healthy (n = 54, shades of blue) and 6 HCV-infected (n = 61, shades of red) donors. (b) Number of mutations in the VH gene in 6 healthy (n = 54) and 6 HCV-infected (n = 61) donors. The black triangles correspond to the magnitude of the IgM memory B cell response. (c) Frequency of mutations of VH genes as calculated by the number of replacement (R; black bars) and silent (S; white bars) nucleotide exchanges per base pair in FWRs and CDRs in healthy (n = 6) and HCV-infected (n = 6) donors.