Fig 4.

In vivo protection and correlation with in vitro neutralization titers. (A) In vivo infection of animals that were passively transferred with the indicated volume of rabbit anti-L2 (11–88×5) serum was compared to control HPV16 infection (no sera). The volume of serum transferred per animal is indicated. All sera were diluted to a total volume of 100 μl/animal. Each symbol represents an individual animal. (B) The correlation of these values with the in vitro neutralization titers (Table 3) obtained for the circulating antibodies from these animals obtained immediately prior to challenge. The fold decrease in the in vivo infection is indicated on the horizontal axis. The average in vitro titer is indicated on the vertical axis. Each circle represents an individual animal. The black circles represent the 20-μl dose, dark gray represents the 2-μl dose, and light gray represent the 0.2-μl dose.