Figure 4.

Short-term effects of P900S and P900SL. Atherogenic diet-fed mice received intraperitoneal administration of P900S or P900SL at a dose of 10 mg/kg twice during 4 days. (a) Liver PCSK9 mRNA levels 4 days after the first injection. (b) Relative serum LDL-C levels 4 days after the first injection. (c) Hepatic LDLR protein expression levels were estimated by western blotting. (d) Serum liver transaminases (AST, ALT) were analyzed. Data represent mean values (± SD). *P < 0.05. ALT, alanine aminotransferase; AST, aspartate aminotransferase; LDL-C, low-density lipoprotein cholesterol; LDLR, low-density lipoprotein receptor; mRNA, messenger RNA.