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. 2012 May 15;1(5):e22. doi: 10.1038/mtna.2012.16

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Copyright © 2012 American Society of Gene & Cell Therapy

Molecular Therapy-Nucleic Acids is an open-access journal published by Nature Publishing Group. This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Dose-dependent responses of physiological parameters to P900SL dosing. (a) Changes in cholesterol fractions upon administration of P900SL analyzed by HPLC. (b) Ratio of serum LDL-C levels after 4 weeks of treatment to before treatment were arranged in order of doses. (c) Liver PCSK9 mRNA levels were measured at all dose levels after 6 weeks of treatment. (d) Hepatic LDLR protein levels were determined 6 weeks after treatment started. (e) The expression levels of genes regulating lipid homeostasis in liver were analyzed. Data represent mean values ± SD. *P < 0.05. n = 5. HDL, high-density lipoprotein; HPLC, high performance liquid chromatography; LDL, low-density lipoprotein; LDL-C, LDL cholesterol; LDLR, LDL receptor; mRNA, messenger RNA; VLDL, very LDL.