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Inhibition of P. berghei exoerythrocytic-stage parasites. Dose-response curves are shown for exoerythrocytic-stage P. berghei parasites treated with HDAC inhibitors SAHA and SB939. Cells were treated with compounds for 53 h following invasion, fixed, stained, and scored by microscopy for successful development of parasites within HepG2 cells. The percent parasite growth compared to vehicle-only control parasite growth (mean ± standard error of the mean [SEM]) is shown.
