Fig 2.

Comparison of miltefosine exposure levels in children and adults: predicted miltefosine concentrations following different dosage regimens. (A) Predicted miltefosine concentration-time curves and intervals for the currently recommended linear 2.5-mg/kg/day miltefosine dose for 28 days. (B) Allometric daily miltefosine dose for 28 days proposed here. The areas of data show the 90% prediction intervals (90% PI; 5th and 95th percentiles) for adults (in gray) and children (between thin black lines); the thicker gray and black lines indicate the median predicted concentrations for adults and children, respectively.