Table 2.
Comparison of the performances of miltefosine population pharmacokinetic models: differences in objective function values and relative between-subject variabilities
| Model | Corresponding equation | ΔOFVa | % BSV [relative % change]b |
|
|---|---|---|---|---|
| CL/F | V2/F | |||
| 1 (linear scaling by WT) | 2 | 0 | 49.6 [0] | 42.7 [0] |
| 2 (linear scaling by FFM) | 3 | −22.7 | 42.8 [-13.8] | 37.4 [-12.3] |
| 3 (allometric scaling by WT) | 4 | −42.0 | 35.1 [-29.3] | 37.7 [-11.7] |
| 4 (allometric scaling by FFM) | 5 | −63.9 | 32.1 [-35.3] | 34.1 [-20.2] |
a
ΔOFV (difference in objective function value) was calculated as ([OFV model value] − [OFV model 1 value]), where model 1 was used as the base model. A negative ΔOFV indicates a better fit of the model.
b
Between-subject variability (BSV) was calculated using the between-subject variance (ω2). BSV values from the base model (model 1) were used as reference values to calculate percent change between the models of the respective parameters.