Table 2.

Comparison of rifapentine pharmacokinetics in guinea pigs, mice, and humans

Test species	Drug dosage	Population	Frequencya	Food	PK sampling dose	n	Cmax (μg/ml)		AUC0–24 (mg · h/liter)		t1/2 (h)
							Median	Range	Median	Range	Median	Range
Guinea pig	50 mg/kg	Healthy	D1	Yes	Single	3	3.16	2.35–3.89	30.25	23.52–45.85	15.61	11.37–21.45
Guinea pig	100 mg/kg	Healthy	D1	Yes	Single	6	11.58	3.55–22.26	187.50	67.32–297.90	21.87	9.05–41.03
Mouseb	10 mg/kg	Healthy	D1	Yes	Single	6	19.26	18.05–21.92	321.49	292.46–354.43	20.56	15.24–22.66
Mousec	10 mg/kg	Healthy	D1	Yes	Single	3	28.23	28.14–29.87	282.44	264.09–304.54	25.58	18.98–33.63
Moused	10 mg/kg	Healthy	D1	Yes	Single	3	14.77	11.41–15.24	237.25	236.14–240.20	21.65	18.98–39.05
Mousee	10 mg/kg	Healthy	SS	Yes	2 wk	3	18.25	17.15–23.68	345.08	267.14–396.40	20.22	19.21–20.46
Humanf	600 mg	TB	SS	No	Weekly	15	13.36	6.52–25.54	182.14	104.28–434.88	13.86	10.33–20.45
Humanf	900 mg	TB	SS	No	Weekly	7	15.14	6.57–36.91	229.08	101.81–504.84	16.08	11.99–18.91
Humanf	1,200 mg	TB	SS	No	Weekly	13	18.95	6.76–54.16	286.96	95.74–706.79	15.30	10.50–19.09

^aD1, once daily; SS, steady state.

^bData from reference 6.

^cData from E. L. Nuermberger, unpublished data.

^dData from reference 30.

^eData from I. M. Rosenthal, R. Tasneen, C. A. Peloquin, M. Zhang, D. Almeida, K. Mdluli, P. C. Karakousis, J. H. Grosset, and E. L. Nuermberger, submitted for publication.

^fData from reference 36.