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Bacterial loads in the lungs of M. tuberculosis-infected mice after treatment with INH delivered by intrapulmonary aerosol or oral gavage. Mice infected with M. tuberculosis (n = 6) were treated with INH by intrapulmonary aerosol delivery (squares) three times a week or oral gavage (triangles) five times a week. Rhomboids, control group of untreated mice. The graph shows the log10 numbers of CFU in the lung (A) and spleen (B). NS, not significant; Rx, treatment; *, P < 0.05.
