Table 3.

Characterization of M. smegmatis mutants used in this study

Parental strain and source of mutants	Drug used for selection	Mutation		No. of mutants
		GyrA	GyrB
KD1163 (wild type)
Fig. 2A, day 3	Ciprofloxacin	None	Y524H	1
Fig. 2A, day 3	Ciprofloxacin	V38G	None	1
Fig. 2A, day 10	Ciprofloxacin	None	Y524H	5
Fig. 2A, day 10	Ciprofloxacin	A91V	None	1
Fig. 2A, day 10	Ciprofloxacin	D95G	None	1
Fig. 2A, day 10	Ciprofloxacin	D95S	None	1
Fig. 2A, day 10	Ciprofloxacin	D95Y	None	1
KD2859 (mutator)
Fig. 4A, day 3	Ciprofloxacin	None	Y524H	1
Fig. 4A, day 3	Ciprofloxacin	E44K	None	2
Fig. 4A, day 3	Ciprofloxacin	E44R	None	1
Fig. 4A, day 10	Ciprofloxacin	None	Y524H	5
Fig. 4A, day 10	Ciprofloxacin	A91V	None	1
Fig. 4A, day 10	Ciprofloxacin	S92P	None	3
KD1163 (wild type)
Fig. 4C, a	PD160793	None	Y524H	1
Fig. 4C, b	PD160793	None	Y524H	1
Fig. 4C, b	PD160793	A91V	None	1
Fig. 4C, b	PD160793	D95Y	None	1
Fig. 4C, c	PD160793	None	Y524H	3
Fig. 4C, c	PD160793	D95S	None	1
Fig. 4C, c	PD160793	D95Y	None	1
KD2859 (mutator)
Fig. 4C, b′	PD160793	None	Y524H	2
Fig. 4C, b′	PD160793	S92P	None	2
Fig. 4C, c′	PD160793	None	Y524H	4
Fig. 4C, c′	PD160793	G89A	None	1
Fig. 4C, c′	PD160793	A91V	Y524H	1
Fig. 4C, c′	PD160793	S92P	None	1