Fig 6.

In vivo effect of TCBZSO coadministration. (A) Plasma concentrations of sulfasalazine and nitrofurantoin in wild-type mice. TCBZSO (50 mg/kg) or the vehicle was administered orally to males 15 min prior to oral administration of sulfasalazine (20 mg/kg). TCBZSO (50 or 100 mg/kg) or the vehicle was administered i.p. to lactating females 5 min prior to i.v. administration of nitrofurantoin (5 mg/kg). (B and C) Milk concentrations (B) and milk/plasma ratios (C) of nitrofurantoin in wild-type and Abcg2^−/− lactating females. TCBZSO (50 or 100 mg/kg) or the vehicle was administered i.p. to mice 5 min prior to i.v. administration of nitrofurantoin (5 mg/kg). Plasma and milk were collected after 30 min of drug administration and analyzed by HPLC. Results are means, and error bars indicate SDs (n = 4 to 7). *, P < 0.05 (significant differences between control and TCBZSO treatments in wild-type mice).