Fig 2.

Hollow-fiber infection model experiments simulating linezolid traditional regimen (A) and front-loaded regimens (B to E) versus MRSA USA300. (A) Traditional regimen: 600 mg every 12 h. (B) Front-loaded regimen: 1,200 mg every 12 h (total, 2 doses) on days 0 to 1 followed by 600 mg every 12 h (total, 18 doses) on days 1 to 10. (C) Regimen of 2,400 mg every 12 h (total, 2 doses) on days 0 to 1 followed by 600 mg every 12 h (total, 18 doses) on days 1 to 10. (D) regimen of 1,200 mg every 12 h (total, 10 doses) on days 0 to 5 followed by 300 mg every 12 h (total, 10 doses) on days 5 to 1. (E) Front-loaded regimen: 2,400 mg (total, 10 doses) on days 0 to 5 followed by 300 mg every 12 h (total, 10 doses) on days 5 to 10.