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. 2012 Jul;56(7):3670–3681. doi: 10.1128/AAC.00308-12

Table 3.

Clonal sequence analysis of the NS3 protease domain from genotype 1b replicon cells selected in the presence of asunaprevir

Clone	Amino acid at NS3 position
Clone	Q41	Q80	Q86	P89	Y105	D168	E173	E176
ASV^c 10× clones
1-1	R^a		R^a			H	G
1-2	R^a		R^a
1-3			R^a			G		G^b
1-4	R^a		R^a
1-5	R^a		R^a			G
1-6	R^a		R^a
1-7	R^a		R^a			G
1-8	R^a		R^a			A
1-9			R^a			G
1-10			R^a			G
ASV 30× clone
1-1	R^a	R	R^a			G
1-2	R^a					V
1-3	R^a					V
1-4					C	V
1-5						V
1-6	R^a					G
1-7						V
1-8						V
1-9						G
1-10	R^a			L^b		Y
1-11	R^a					V
1-12	R^a					A

^a

Present in wild-type cell line.

^b

Published cell culture-adaptive substitution.

^c

ASV, asunaprevir.