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Baseline NS3 protease polymorphisms in patients from single- and multiple-ascending-dose studies
| Amino acid substitutiona | No. of patients with NS3 PI resistance-associated substitution |
|
|---|---|---|
| SAD (n = 10) | MAD (n = 15) | |
| V55I | 1 | |
| Q80K | 5 | 5 |
| S122G | 1 | |
| S122T | 1 | |
| I170Vb | 1 | |
| V170Ic | 1 | |
| S122R-V170I | 1 | |
Amino acids monitored included V36, F43, T54, V55, D79, Q80, S122, R155, A156, V158, D168, and V/I170.
Genotype 1a consensus, I170.
Genotype 1b consensus, V170.
