Table 5.
Clinical chemistry summary for test animals measured on day 6
| Group and dose (mg/kg/day) | LDH (U/liter) | AST (U/liter) | ALT (U/liter) | TRI (mg/dl) | ALB (g/dl) | AGR | CHO (mg/dl) | BUN (mg/dl) |
|---|---|---|---|---|---|---|---|---|
| Vehiclea, 0 | 165 ± 45 | 70 ± 7.5 | 40 ± 12 | 181 ± 22.8 | 3.9 ± 0.17 | 4 ± 0.9 | 90 ± 4.6 | 21 ± 2.6 |
| DB1955 | ||||||||
| 100a | 155 ± 49.3 | 64 ± 9.4 | 35 ± 4.7 | 188 ± 52.8 | 3.8 ± 0.35 | 3 ± 1.1 | 99 ± 6.3 | 22 ± 1.9 |
| 200a | 441 ± 487.3 | 143 ± 166.9 | 86 ± 57.6 | 131 ± 47.3 | 3.6 ± 0.35 | 3 ± 0.4 | 101 ± 6.1 | 25 ± 4.4 |
| 500a | 202 ± 73.5 | 75 ± 30.6 | 41 ± 27.8 | 119 ± 36.6d | 3.6 ± 0.23 | 3 ± 0.4 | 114 ± 8.6 | 36 ± 7.7 |
| DB1960 | ||||||||
| 100a | 228 ± 90 | 91 ± 49.7 | 42 ± 11.1 | 92 ± 21.9e | 3.5 ± 0.15 | 3 ± 0.5 | 87 ± 6.4 | 22 ± 4.2 |
| 200a | 257 ± 34.6 | 163 ± 42.8 | 109 ± 38.1e | 64 ± 14.3e | 3.2 ± 0.25d | 2 ± 0.0e | 109 ± 8.6 | 29 ± 6.8 |
| 500b | 820 ± 422.6e | 364 ± 134.7e | 91 ± 24.7d | 55 ± 14.2c,e | 3.3 ± 0.41e | 2 ± 0.5e | 129 ± 25.7e | 108 ± 57.5e |
a
The values are means ± standard deviations of experimental groups of five animals.
b
The values are means ± standard deviations of experimental groups of eight animals.
c
The values are means ± standard deviations of experimental groups of seven animals.
d
Significant difference from control (P < 0.05).
e
Significant difference from control (P < 0.01).